Publication and links
Please see below list of published, in press and submitted papers to date with a brief description of their relevance to the Fenzian therapy system:
1. M Griffin, SA Iqbal, A Sebastian, J Colthurst, A Bayat
Degenerate wave and capacitive coupling increase human MSC invasion and proliferation while reducing cytotoxicity in an in vitro wound healing model. PLoS One. 2011;6(8):e23404. Epub 2011 Aug 16. PubMed PMID: 21858102; PubMed Central PMCID: PMC3156742.
- first study to show the superior effect of Fenzian wave on mesenchymal stem cells with application for stem cell therapy in the future. Fenzian stimulated good growth in the mesenchymal cells and at the same time caused the least ‘collateral damage’. Although the non-Fenzian AC waveform seemed to stimulate the cells it also caused unwanted cytotoxic effects. Obviously, Fenzian has significantly greater attraction as a treatment modality if it can create useful outcomes on stems cells without doing damage.
2. D Perry, J Colthurst, P Giddings, DA McGrouther, J Morris, A Bayat
Treatment of symptomatic abnormal skin scars with electrical stimulation. J Wound Care. 2010 Oct;19(10):447-53. PubMed PMID: 20948493.
- first clinical study to show the positive effect Fenzian treatment of abnormal skin scarring. All patients with symptomatic scars had a positive outcome. Individuals with keloid scars showed the greatest pain relief, those with hypertrophic scars had the best improved itch symptoms, while scar score reduction was better achieved in hypertrophic and surgical scar cases. Our results suggest that patient age and the number of problematic scars present affects response to biofeedback electrical stimulation. This study provided encouraging early evidence of the use of biofeedback electrical stimulation in the successful management of symptomatic abnormal skin scarring.
3. A Sebastian, F Syed, DA McGrouther, J Colthurst, R Paus, A Bayat
A novel in vitro assay for electrophysiological research on human skin fibroblasts: degenerate electrical waves downregulate collagen I expression in keloid fibroblasts. Exp Dermatol. 2011 Jan;20(1):64-8. doi:10.1111/j.1600-0625.2010.01150.x. Epub 2010 Aug 12. PubMed PMID: 20707813.
- First study to demonstrate the in vitro development of Fenzian wave by analyzing the Fenzian device and demonstrating its effect on skin cells in comparison to other wave forms. Namely, we identify DW as a promising, novel therapeutic strategy for suppressing excessive collagen I formation in keloid disease. We have shown that Fenzian (referred to as DW) offers a form of electrostimulation that effectively downregulates collagen I production in keloid fibroblasts in vitro, without being toxic to normal human dermal fibroblasts. This has significant implications for early hints of a scientific proof of the value of the Fenzian waveform in wound healing.
4. A Sebastian, F Syed. D Perry, V Balamurugan, J Colthurst; IH Chaudhry, A Bayat
Acceleration of cutaneous healing by electrical stimulation: Degenerate electrical wave form down regulates inflammation, up regulates angiogenesis and advances remodeling in temporal punch biopsies in a human volunteer study. WRR.
- First study to show positive effect of Fenzian treatment in accelerating repair and reducing inflammation in an acute wound biopsy model in 20 healthy volunteers. The combined value of the reduction in inflammation, the formation of new vessels and the acceleration of new modeling of the wound structure in this elegantly designed study provide convincing clinical indications of the value of Fenzian in wound recovery.
5. A Sebastian, E Allan, D Allan, J Colthurst, A Bayat
Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combinatorial therapy. Journal of Dermatological Sciences. 2011.
- First study to show the effect of combining Fenzian wave with PDT to enhance treatment effect. It is very difficult sometimes for therapeutic creams to enter keloid cells to carry out their work. In this study, Fenzian was combined with PDT and provided a most impressive impact on traditionally untreatable keloid.
6. M Griffin, A Sebastian, J Colthurst, A Bayat
Degenerate Electrical Waveform Enhances the Differentiation and Mineralization of Osteoblasts in an in vitro Electrical Stimulation Model
Journal of Orthopaedic Research. 2011.
· First study to show the effect of Fenzian wave on osteoblasts with implication for fracture healing. In this in vitro study Fenzian was shown to have a significant impact on osteoblasts (which lay down new bone). This is consistent with the clinical effects which have been shown in two cases of bone fracture non-union in the Hungerford clinic. Again, this may demonstrate a mechanism of stimulation of healing extending into bone cells on top of the previous studies which have demonstrated its impact on fibroblasts and new blood vessel formation.
7. S Ud-Din, D Perry, P Giddings, J Colthurst, K Zaman, S Cotton, S Whiteside, J Morris, ABayat
Application of Fenzian wave electrical stimulation enhances cutaneous healing: evidenced by a temporal skin biopsy model in human volunteers. WRR. 2011.
· First clinical study of healthy volunteers undergoing biopsies with and without Fenzian which were monitored clinically by non-invasive devices showing benefit of the Fenzian treatment system in enhancing angiogenesis in acute wounds. Using a number of genetic markers the progress of healing was tracked and it was clearly demonstrated that in a 21 day study, wounds reached a state of healing four/five days sooner than expected – a 22% reduction in wound healing time.
8. Selvi Jeyaseelan1, Ian Hambleton1, Nkemcho Ojeh1, Noel Archer1, Amy Browne1, Natasha Sobers-Grannum1, Pam Giddings2, James Colthurst2, Gregory B. Diette3
1Faculty of Medical Sciences, The University of the West Indies, Cave Hill, Barbados; 2Fenzian Ltd, Hungerford UK, 3Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Tolerability of Fenzian ElectrobiofeedbackTreatment for Asthma in a Caribbean Population
Poster presentation at American Thoracic Society, San Francisco, May 2012
“My neck hurt so much that turning over at night I had to turn a tiny bit at a time - in 20 small (excruciatingly sore) stages. After Fenzian treatment, I have full movement again.”
Osteoporotic collapse of the neck - Cilla